Gopichand made his debut as a hero with the film Tholi Valapu. He played negative roles in his next films Jayam, Nijam and Varsham. Following the positive reception towards his performance in Jayam, he reprised his role in the film’s Tamil-language remake of the same title. He made his re-entry as hero with the films Yagnam in 2004 and Andhrudu in 2005. In 2006, he starred in the commercially successful Ranam and the commercially unsuccessful Raraju. His 2007 releases Okkadunnadu and Lakshyam, and the 2008 release Souryam Out Of Four Two were commercially successful (except Ontari), following which he collaborated once again with Souryam director Siva for their 2009 release Sankham.
His 2010 release Golimar saw him playing an encounter specialist inspired by the real-life cop Daya Nayak. In 2011, he acted in Mogudu and Wanted but both were commercial failures. In 2013, he reunited with director Chandra Sekhar Yeleti (after Okkadunnadu) for the action-adventure film Sahasam which became his biggest commercially successful film at that time. In 2014, he starred in Loukyam commercially became his most successful film. In 2015, he starred in Jil and Soukhyam. In 2017, he starred in Goutham Nanda and Oxygen which were both commercially unsuccessful. His next film Aaradugula Bullet was slated to release the same year but remains unreleased. In 2018, he played a vigilante in Pantham, which was his 25th film. In 2019, he played a spy in Chanakya.